A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus
作者： Bruce E. Hunter , Christopher M. de Fiebre , Roger L. Papke , William R. Kem , Edwin M. Meyer
DOI: 10.1016/0304-3940(94)90433-2
关键词:
摘要: Long-term potentiation (LTP) can be modulated by a number of neurotransmitter receptors including muscarinic and GABAergic receptor types. We have found that novel nicotinic agonist, 2,4-dimethoxybenzylidene anabaseine (DMXB), facilitated the induction LTP in hippocampus dose-dependent mecamylamine-sensitive manner. DMXB displaced high affinity [125I]alpha-bungarotoxin [3H]acetylcholine binding rat brain. Xenopus oocyte studies demonstrated has agonist activity at alpha 7 but not 4/beta 2 subtypes. These results indicated is with apparent specificity for 7/alpha-bungarotoxin subtype indicate activation capable modulating long-term potentiation.
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