Fine mapping of quantitative trait nucleotides underlying thrombin-activatable fibrinolysis inhibitor antigen levels by a transethnic study.
作者： Corinne Frère , David-Alexandre Tregouet , Pierre-Emmanuel Morange , Noémie Saut , Dinar Kouassi
DOI: 10.1182/BLOOD-2006-01-008094
关键词:
摘要: Recent studies revisiting the association between plasma thrombin-activatable fibrinolysis inhibitor (TAFI) Ag levels and polymorphisms of CPB2 gene (coding for TAFI) suggested that TAFI were influenced by 2 major quantitative trait nucleotides (QTNs) in European whites. However, strong linkage disequilibrium (LD) whites did not allow one to distinguish which could be putative QTNs. To get a better insight into identification QTNs, transethnic haplotype analysis contrasting populations African subjects was performed using 13 polymorphisms. Results analyses 3 QTNs had independent effects explained about 15% variability, consistently populations. The lower LD observed population enabled us identify 1583T>A SNP located 3′UTR as these whereas -2599C>G -2345--2344insG SNPs 5′ region might other A phylogenetic study occurred before period migration “out Africa.” Although this comparison contributed map further are required clarify role promoter region.
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