Genetic variation in thrombin-activatable fibrinolysis inhibitor is associated with the risk of diabetic nephropathy

摘要: Diabetic nephropathy is a kidney disease or damage that results as complication of diabetes, especially Type 2 while albuminuria an early marker for diabetic it can predict cardiovascular events and mortality in patients. A potent inhibitor fibrinolysis, the thrombin-activatable fibrinolysis (TAFI) has been isolated characterized from human plasma. We investigated associations activity-related variants TAFI coding gene (505A/G, 1040C/T) with risk by examining 297 samples including 140 health controls 157 confirmed grades were further categorized urine albumin excretion (UAE)-to-creatinine ratios (ACR). found little difference was statistically significant terms 505A/G among patients controls. While at 1040C/T, detected frequency T allele group significantly smaller than control (15.6% vs 25.7%, respectively; p<0.05). This due to relative decrease T/T homozygotes (p<0.05, 95% odds ratio 0.28, confidence interval 0.11–0.70). Surprisingly, only observed initial stages. study clearly indicates that, strongly associated increased subset general population, implying confers protection against onset homozygosity may function recessive trait.