Development of a model to simulate infection dynamics of Mycobacterium bovis in cattle herds in the United States

作者: Rebecca L. Smith , Ynte H. Schukken , Zhao Lu , Rebecca M. Mitchell , Yrjo T. Grohn

DOI: 10.2460/JAVMA.243.3.411

关键词:

摘要: Objective—To develop a mathematical model to simulate infection dynamics of Mycobacterium bovis in cattle herds the United States and predict efficacy current national control strategy for tuberculosis cattle. Design—Stochastic simulation model. Sample—Theoretical States. Procedures—A within-herd M transmission following introduction 1 latently infected cow was developed. Frequency- density-dependent modes 3 tuberculin test–based culling strategies (no test-based culling, constant [annual] testing with slaughterhouse detection–based culling) were investigated. Results evaluated herd sizes over 10-year period validated via known outbreaks infection. Results—On basis 1,000 simulations (1,000 each) at replacement rates typical dairy (0.33/y), median time detection medium-...

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