DNA Double-Strand Breakage as an Endpoint to Examine Metal and Radionuclide Exposure Effects to Water Snakes on a Nuclear Industrial Site
作者： Stephanie M. Murray , Karen F. Gaines , James M. Novak , Michael Gochfeld , Joanna Burger
DOI: 10.1080/10807031003670337
关键词:
摘要: ABSTRACT This study examined metal levels (especially U and Ni) in the tail tissues of water snakes from contaminated (Tim's Branch) reference areas on Department Energy's Savannah River Site (SRS). Home ranges were quantified to determine ratio habitat that they use relation better estimate exposure Compared conventional methods do not. The assessment indicated could expect at 3–4 orders magnitude greater than Agency for Toxic Substances Disease Registry's Minimum Risk Level (MRL) ingestion amphibians fish. Ni U, addition Se, Mn, Cu, related increased DNA double-strand breakage (DDSB) snakes. We report burdens each individually, but results DDSB these metals did not behave independently, as a suite. If we have secondary endpoint (DDSB), might assumed e...
cabdirect.org
core.ac.uk 
sci-hub.se 参考文章(37)
Kym Rouse Campbell, Todd S. Campbell, The Accumulation and Effects of Environmental Contaminants on Snakes: A Review Environmental Monitoring and Assessment. ,vol. 70, pp. 253- 301 ,(2001) , 10.1023/A:1010731409732
Ecotoxicology of amphibians and reptiles CRC Press. ,(2010) , 10.1201/EBK1420064162
K Tsuzuki, M Sugiyama, N Haramaki, DNA single-strand breaks and cytotoxicity induced by chromate(VI), cadmium(II), and mercury(II) in hydrogen peroxide-resistant cell lines. Environmental Health Perspectives. ,vol. 102, pp. 341- 342 ,(1994) , 10.1289/EHP.94102S3341
Andrea Hartwig, Current aspects in metal genotoxicity. Biometals. ,vol. 8, pp. 3- 11 ,(1995) , 10.1007/BF00156151
Derrick W Sugg, Ronald K Chesser, Janet A Brooks, Brian T Grasman, The association of DNA damage to concentrations of mercury and radiocesium in largemouth bass Environmental Toxicology and Chemistry. ,vol. 14, pp. 661- 668 ,(1995) , 10.1002/ETC.5620140414
J. Burger, J. W. Gibbons, Trace elements in egg contents and egg shells of slider turtles (Trachemys scripta) from the Savannah River Site Archives of Environmental Contamination and Toxicology. ,vol. 34, pp. 382- 386 ,(1998) , 10.1007/S002449900334
Nelwyn T. Christie, The synergistic interaction of Nickel(II) with dna damaging agents Toxicological & Environmental Chemistry. ,vol. 22, pp. 51- 59 ,(1989) , 10.1080/02772248909357423
L.R. Shugart, M.K. Gustin, D.M. Laird, D.A. Dean, Susceptibility of DNA in aquatic organisms to strand breakage: Effect of x-rays and gamma radiation Marine Environmental Research. ,vol. 28, pp. 339- 343 ,(1989) , 10.1016/0141-1136(89)90257-2
David E. Amacher, Simone C. Paillet, Induction of trifluorothymidine-resistant mutants by metal ions in L5178Y/TK+/− cells Mutation Research. ,vol. 78, pp. 279- 288 ,(1980) , 10.1016/0165-1218(80)90110-X
William A. Hopkins, Reptile toxicology: Challenges and opportunities on the last frontier in vertebrate ecotoxicology Environmental Toxicology and Chemistry. ,vol. 19, pp. 2391- 2393 ,(2000) , 10.1002/ETC.5620191001