Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model

摘要: We have previously developed a model of human cardiopulmonary (CP) system, which included the whole body circulatory gas exchange at both lungs and peripheral tissue, central nervous control arterial pressure ventilation. now add more detailed description cerebral circulation, cerebrospinal fluid (CSF) dynamics brain exchange. Two blood flow (CBF) regulatory mechanisms are included: autoregulation CO/sub 2/ reactivity. The is first validated in an open-loop configuration using input data generated by as inputs, then integrated into CP to form model. It this that we used study response thigh cuff experiment. Our demonstrated ability closely mimic experimental findings provide predictions regarding state tissue gas-exchange. With further refinement, it may serve useful tool clinical evaluation oxygenation.