Phase II study. Concurrent chemotherapy and radiotherapy with nitroglycerin in locally advanced non-small cell lung cancer.
作者： Oscar Arrieta , Mónika Blake , María Dolores de la Mata-Moya , Francisco Corona , Jenny Turcott
DOI: 10.1016/J.RADONC.2014.01.021
关键词:
摘要: Abstract Background Nitroglycerin, a nitric oxide donor agent, reduces the expression of hypoxia-inducible factor-1α (HIF-1α) and could be normalizer tumor microenvironment. Both factors are associated with chemo-radio-resistance. The aim this study was to determine safety profile efficacy nitroglycerin administration chemo-radiotherapy in patients locally advanced non-small cell lung cancer (NSCLC). Methods This is phase II trial NSCLC treated cisplatin vinorelbine plus concurrent radiotherapy. A 25-mg NTG patch administered for 5days (1day before 4days after chemotherapy induction consolidation) all day during chemo-radiotherapy. VEGF plasmatic level determined two cycles chemotherapy. Results Thirty-five were enrolled trial. Sixty-three percent achieved an overall response chemotherapy, 75% median progression-free survival 13.5months (95% CI, 8.8–18.2), 26.9months 15.3–38.5). Reduction better OS. toxicity related included headache (20%) hypotension (2.9%). Conclusions addition chemoradiotherapy has acceptable supports possibility add randomized warranted confirm these findings.
sci-hub.se 参考文章(33)
Oscar Arrieta, Enrique Guzman-de Alba, Luis Felipe Alba-López, Alicia Acosta-Espinoza, Jorge Alatorre-Alexander, José Francisco Alexander-Meza, Silvia Rosa Allende-Pérez, Salvador Alvarado-Aguilar, Margarita E Araujo-Navarrete, Luis Marcelo Argote-Greene, Cinthia Alejandra Aquino-Mendoza, Alma Magdalena Astorga-Ramos, Horacio Austudillo-de la Vega, Alejandro Aviles-Salas, Luis Javier Barajas-Figueroa, Ninnbe Barroso-Quiroga, Monica Blake-Cerda, Paula Anel Cabrera-Galeana, German Calderillo-Ruiz, Alma Delia Campos-Parra, Ana María Cano-Valdez, Daniel Capdeville-Garcia, Graciano Castillo-Ortega, Catalina Casillas-Suarez, Patricia Castillo-González, José Francisco Corona-Cruz, María Elma Correa-Acevedo, Séfora Sonciry Cortez-Ramírez, Jhony Alberto de la Cruz-Vargas, Jaime G de la Garza-Salazar, María Dolores de la Mata-Moya, María Eugenia Domínguez-Flores, Hugo Ricardo Domínguez-Malagón, Luis Manuel Domínguez-Parra, Alfredo Domínguez-Peregrina, Jaime Durán-Alcocer, María Isabel Enríquez-Aceves, Abelardo Elizondo-Ríos, Moisés Dante Escobedo-Sánchez, PE de Villafranca, Alberto Flores-Cantisani, Juan Pablo Flores-Gutiérrez, Francisco Franco-Marina, Edwin Efraín Franco-González, Ramón Antonio Franco-Topete, Homero Fuentes-de la Peña, Susana Galicia-Amor, Dolores Gallardo-Rincón, Armando Gamboa-Domínguez, Jorge García-Andreu, Claudia María García-Cuéllar, María Cecilia García-Sancho-Figueroa, Rogelio García-Torrentera, Raquel Gerson-Cwilich, Arturo Gómez-González, León Green-Schneeweiss, H Gutiérrez-Velázquez, C Ibarra-Pérez, E Jiménez-Fuentes, P Juárez-Sánchez, A Juárez-Ramiro, J Kelly-García, R Kuri-Exsome, JM Lázaro-León, E León-Rodríguez, S Llanos-Osuna, U Loyola-García, JS López-González, MA Loustaunau-Andrade, EO Macedo-Pérez, L Machado-Villarroel, M Magallanes-Maciel, L Martínez-Barrera, J Martínez-Cedillo, G Martínez-Martínez, A Medina-Esparza, A Meneses-García, A Mohar-Betancourt, J Morales-Gómez, D Motola-Kuba, MP Nájera-Cruz, MA Ocampo-Ocampo, MD Ochoa-Vázquez, CA Olivares-Torres, A Palomar-Lever, M Patiño-Zarco, R Pérez-Padilla, YR Peña-Alonso, AR Pérez-Romo, Aquilino Pérez, PM Pinaya-Ruíz, MA Pointevin-Chacón, JJ Poot-Braga, R Posadas-Valay, M Ramirez-Márquez, I Reyes-Martínez, J Robledo-Pascual, J Rodríguez-Cid, CE Rojas-Marín, E Romero-Bielma, JE Rubio-Gutiérrez, JA Sáenz-Frías, MA Salazar-Lezama, K Sánchez-Lara, P Santillán-Doherty, J Alejandro-Silva, JL Téllez-Becerra, V Toledo-Buenrostro, L Torre-Bouscoulet, L Torecillas-Torres, M Torres, V Tovar-Guzmán, JG Turcott-Chaparro, JJ Vázquez-Cortés, ME Vázquez-Manríquez, N Vilches-Cisneros, JF Villegas-Elizondo, MM Zamboni, J Zamora-Moreno, JW Zinser-Sierra, None, [National consensus of diagnosis and treatment of non-small cell lung cancer]. Revista De Investigacion Clinica. ,(2013)
I Díez, S Calatayud, C Hernández, E Quintana, JE O'Connor, JV Esplugues, MD Barrachina, Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1α in macrophages during aspirin-induced mesenteric inflammation British Journal of Pharmacology. ,vol. 159, pp. 1636- 1645 ,(2010) , 10.1111/J.1476-5381.2010.00654.X
William DeGraff, Janet Gamson, David A. Wink, Murali C. Krishna, James B. Mitchell, Larry K. Keefer, Hypoxic Mammalian Cell Radiosensitization by Nitric Oxide Cancer Research. ,vol. 53, pp. 5845- 5848 ,(1993)
K S Albain, V W Rusch, J J Crowley, T W Rice, A T Turrisi, J K Weick, V A Lonchyna, C A Presant, R J McKenna, D R Gandara, Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: mature results of Southwest Oncology Group phase II study 8805. Journal of Clinical Oncology. ,vol. 13, pp. 1880- 1892 ,(1995) , 10.1200/JCO.1995.13.8.1880
Lisa K. Folkes, Peter O’Neill, DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication Nitric Oxide. ,vol. 34, pp. 47- 55 ,(2013) , 10.1016/J.NIOX.2013.04.005
Hiroshi Maeda, Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjugate Chemistry. ,vol. 21, pp. 797- 802 ,(2010) , 10.1021/BC100070G
Thilo Hagen, Cormac T Taylor, Francis Lam, Salvador Moncada, Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α Science. ,vol. 302, pp. 1975- 1978 ,(2003) , 10.1126/SCIENCE.1088805
Maher Soliman, Ala Yaromina, Steffen Appold, Daniel Zips, Carsten Reiffenstuhl, Andreas Schreiber, Howard D. Thames, Mechthild Krause, Michael Baumann, GTV differentially impacts locoregional control of non-small cell lung cancer (NSCLC) after different fractionation schedules: subgroup analysis of the prospective randomized CHARTWEL trial. Radiotherapy and Oncology. ,vol. 106, pp. 299- 304 ,(2013) , 10.1016/J.RADONC.2012.12.008
B J Moeller, M W Dewhirst, HIF-1 and tumour radiosensitivity. British Journal of Cancer. ,vol. 95, pp. 1- 5 ,(2006) , 10.1038/SJ.BJC.6603201
M. Baumann, T. Herrmann, R. Koch, W. Matthiessen, S. Appold, B. Wahlers, L. Kepka, G. Marschke, D. Feltl, R. Fietkau, V. Budach, J. Dunst, R. Dziadziuszko, M. Krause, D. Zips, Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC) Radiotherapy and Oncology. ,vol. 100, pp. 76- 85 ,(2011) , 10.1016/J.RADONC.2011.06.031