Balancing Inflammation: The Link between Th17 and Regulatory T Cells.

摘要: CD4(+) T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic functional characteristics. IL-17-producing cells (Th17 cells) represent a subset the lineage. Recent evidence suggests that Th17 carry out effector functions similar to cytotoxic CD8(+) play an important role clearance extracellular pathogens fungi. differentiation function closely related development regulatory (TREG). The balance between these two populations is essential for immune homeostasis dysregulation this has been implicated variety inflammatory conditions including autoimmunity, allograft rejection, tumorigenesis. Emerging reports significant amount plasticity compartments, mechanisms by which communicate influence other just beginning be understood. In review, we highlight recent findings detailing driving TREG discuss biologic consequences their relationship.