Investigation on a new scleroglucan/borax hydrogel: structure and drug release.
作者： Antonio Palleschi , Tommasina Coviello , Gianfranco Bocchinfuso , Franco Alhaique
DOI: 10.1016/J.IJPHARM.2006.05.029
关键词:
摘要: The aim of this work is to elucidate the structure new hydrogel prepared with scleroglucan (Sclg) and borax, suitable for drug delivery, applying theoretical approaches, explain its very peculiar swelling. possible linkages borate ions have been investigated original parameters 4,6-gluco-borate moiety introduced. structures relative Sclg chains in presence borax mutual arrangements among triple helices are given. According molecular dynamics simulations, most probable assembly network proposed, without three tested model drugs different dimensions: theophylline (TPH), Vitamin B12 (Vit. B12) myoglobin (MGB). supramolecular structure, formed via chemical physical polysaccharidic chains, built up taking into account steric hindrance entrapped molecules. It shown that analysis can be a useful tool capable shed some light on anomalous swelling hydrogel, release, giving insight release rate guest
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