The effect of gestation and fetal mismatching on the development of autoimmune diabetes in non-obese diabetic mice.

摘要: The impact of gestation and fetal-maternal interactions on pre-existent autoimmune beta cell destruction is widely unknown. aim this study was to investigate the influence per se fetal mismatching onset diabetes in female non-obese diabetic (NOD) mice. We examined cumulative frequencies NOD dams mated syngeneic NOD, haploidentical CByB6F1/J fully mismatched C57BL/6J male Pregnancy from males neither increased nor accelerated (71% by age 28 weeks) compared unmated mice (81% weeks; P = 0·38). In contrast, delayed observed when were at 10 weeks with major histocompatibility complex (MHC) (38% 0·01). Mating MHC (72% 0·22) or mating later time-point 13 (64% versus 91% litter-matched controls; 0·13) did not delay significantly females. Because infusion mouse splenocytes found previously prevent we looked for, but no evidence of, persistent chimeric lymphocytes paternal origin within dams' splenocytes. Gestation appears have aggravating ameliorating effects destruction, pregnancy partially delays