Effect of pregnancy on collagen-induced arthritis in mice.

摘要: Bovine type II collagen administered to non-pregnant female DBA/1 mice caused arthritis in 55% of animals with a mean onset time 70 days following immunization. Of collagen-treated females subsequently becoming syngeneically pregnant before the arthritis, all developed disease within 10 parturition, representing an earlier onset, compared females, 41 days. This also occurred allogenic pregnancy, but did not occur resorbing their fetuses (only syngeneic pregnancies were examined). In at conception significant remission was observed during pregnancy followed by exacerbation post-partum. sequence remissions and exacerbations post-partum each (parties up four studied). The treatment multiparous demonstrated that does provide long-term protection against development or progression as such equally susceptible collagen-induced (CIA) described above. modifying effect on CIA is complex appear be result single pregnancy-associated phenomenon.