Increased respiratory chemosensitivity induced by oral almitrine in healthy man

摘要: Cardiorespiratory effects of 50 mg and 100 doses almitrine placebo given orally on separate test days to twelve healthy volunteers were assessed in a double-blind crossover study. The drug caused no significant changes ventilation, mixed venous CO2 tension, metabolic rate, heart rate or blood pressure while they resting breathing room air. With progressive hypercapnia, however, the ventilatory response increased by 5% after dose (NS) 27% (P < 0.05). There greater increases hypoxia 78% 0.01) 120% 0.01), which was also significantly than increase 0.01). In contrast there only minor inconsistent chemosensitivity administering placebo. findings are consistent with an agonist action peripheral chemoreceptors suggest that it may have clinical value managing respiratory failure due hypoventilation.