Respective contribution of plasma branched-chain amino acids and 2-keto acids to the hepatic metabolism of the carbon moiety of branched-chain amino acids in fed rats.

摘要: The splanchnic balances of branched-chain amino acids (BCAA) and ketoacids (BCKA) concentrations were compared in rats fed a 15% (basal) or 70% (HP) casein diet. Arterial BCAA four- to fivefold BCKA twofold higher HP diet than basal In diet, proportion (45-58%) was removed by the liver (7-12%). Thus, plasma probably major source substrates for hepatic dehydrogenase. uptake 10 times greater owing their extraction; only twice as great; thus minor metabolism. both groups, ketomethylvalerate (KMV) less efficient ketoisovalerate (KIV) ketoisocaproate (KIC) uptake. Studies metabolism intraportal loads showed that capacities KIV KIC high, KMV plateaued at lower portal concentrations. With diets, may be site utilization; interorgan transfer carbon moiety does not keep pace with an increased availability BCAA.