Cortical evoked potential changes during classical conditioning of morphine dependence in rats

摘要: Abstract A classical conditioning experiment was designed to determine if a conditioned neural response would develop and persist in cortical evoked potentials elicited by foreleg stimulus (CS+) that paired with morphine administration during the development of dependence subsequent withdrawal. other (CS−) presented explicitly unpaired delivery. After established, rats were taken from experimental chamber withdrawn for 6 days their home cages. Finally, testing phase, animals returned stimuli presented. The CS+ either or saline injections. Changes due both effects only observed. response, however, present recorded those receiving contralateral stimulation as CS+. persisted after withdrawal drug-free morphine-intoxicated animals. These results provide support relapse theory nonextinguished is retained However, further experiments are necessary these responses can elicit drug-seeking behavior.