Antibody-Mediated Drug Delivery in Cancer Therapy

摘要: The lack of specificity currently available chemo- and radiotherapeutic agents constitutes a major obstacle to the treatment cancer. difference between malignant normal cells in regards their sensitivity cytotoxic therapies is, most cases, not sufficient allow potentially curative doses drugs or radiation be administered without unacceptable toxicity cells. Thus, administration therapeutic these during cancer patients also damages rapidly proliferating host tissues such as hematopoietic cells, hair follicles, epithelial lining gastrointestinal tract. It is generally accepted that usefulness many would enhanced if were rendered more tumor-selective.