Role of an anti-epidermal growth factor receptor in treating cancer.
作者： Harlan W. Waksal
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摘要: Recent technological advances, together with the discovery of important role many growth factors play in modulating cell proliferation and differentiation, have led to development novel therapeutic agents for treatment cancer. In particular, advances hybridoma technology molecular engineering permitted humanized or chimeric monoclonal antibodies capable interfering factor signaling pathways. One promising target interest is epidermal receptor (EGFr), which activated by ligands EGF TGF-α. This ligand interaction plays a crucial survival human cancers. A (human/mouse) antibody cetuximab (IMC-C225) targets EGFr has potential clinical value as an anticancer agent.
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