XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression.
作者： Roberta Bartolucci , Jia Wei , Jose Javier Sanchez , Laia Perez-Roca , Imane Chaib
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摘要: Abstract Background Molecular markers can help identify patients with early-stage non–small-cell lung cancer (NSCLC) a high risk of relapse. Excision repair cross-complementing 1 (ERCC1), Xeroderma pigmentosum group G (XPG), and breast (BRCA1) are involved in DNA damage repair, whereas ribonucleotide reductase M1 (RRM1) is implicated synthesis. Expression levels these molecules might therefore have prognostic role cancer. Patients Methods We examined ERCC1, RRM1, XPG, BRCA1 mRNA by real-time quantitative polymerase chain reaction 54 stage IB-IIB resected NSCLC. A strong correlation was observed between the 4 genes. Results For low BRCA1, regardless XPG expression levels, disease-free survival (DFS) not reached. intermediate/high DFS 50.7 months. However, for low/intermediate decreased to 16.3 months ( P = .002). Similar differences were overall survival, median reached or XPG. Conversely, dropped 25.5 .007). Conclusion identified as independent factors both DFS. High confers poor prognosis early NSCLC, combination still further increases shorter survival. These findings optimize customization adjuvant chemotherapy.
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