Dynamic development of homing receptor expression and memory cell differentiation of infant CD4+CD25high regulatory T cells.

摘要: Migration of CD4 + CD25 FOXP3 regulatory T cells (Treg) is important for suppressing immune responses in different tissues. Previous studies show that the majority Treg at birth express gut homing receptor α 4 β 7 and only few CCR4, while reverse pattern found adults. The age which switch occurs vivo not known. In this study, we show, a prospective study human infants from to 3 years age, CCR4 commences between 1 1/2 also had started their memory phenotype. naive but adults, both expression on corresponds actual migration properties, because cord blood migrate foremost toward gut-associated chemokine CCL25. cell numbers increase rapidly circulation during first days life indicating conversion suppressive high precursors. These findings suggest primary site stimulation exogenous Ags 18 mo more extra-intestinal phenotype thereafter.