Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells

摘要: Forkhead Box P3(+) (FOXP3(+)) T cells are regulatory important for maintaining immune tolerance. While chemokine- and other homing-receptors cell migration, it has been unclear how they regulated in FOXP3(+) cells. We thoroughly investigated, ex vivo vitro, the regulation of chemokine receptor expression on human neonatal cord blood, adult peripheral tonsils. found that undergo changes trafficking receptors according to their stages activation differentiation. divided into CD45RA(+) (naive type) CD45RO(+) (memory CD45RA(+)FOXP3(+) mainly express lymphoid tissue homing (CD62L, CCR7, CXCR4), while CD45RO(+)FOXP3(+) highly both Th1 Th2-associated along with at reduced frequencies. Up-regulation Th1/Th2-associated begins is completed after differentiation Some such as CXCR5 CXCR6 preferentially expressed by many a specific stage (CD69(+)CD45RO(+)) Our vitro study demonstrated indeed switch from (secondary homing) type (lymphoid nonlymphoid homing). The orderly potentially tissue-specific migration responses humans.