Utility of untimed single urine protein/creatinine ratio as a substitute for 24-h proteinuria for assessment of proteinuria in systemic lupus erythematosus

摘要: In this study, we determined: (1) the utility of an untimed sample urine protein/creatinine ratio (PCR) as a screening test for proteinuria, (2) its ability to accurately measure and (3) cutoff values PCR predicting protein content in 24-h collection sample (24hP) 0.5, 1.0, 2.0 g/day. Analysis was performed on data from single lupus cohort (2008–2014). Proteinuria measured 24hP with PCR. On basis 24hP, samples were divided into 4 groups: group 1, <0.5 g/day; 2, 0.5–0.99 g/day; 3, 1–1.99 g/day; 4, ≥2 g/day. To determine validity Pearson correlation coefficient determined normal (<0.05 g/mmol) (<0.5 g/day). The sensitivity, specificity, positive predictive value (PPV), negative (NPV) calculated. level addition between PCR, agreement by intraclass coefficient, concordance Bland-Altman plot 24hP/24hC best cutoffs 2.0 g/day receiver operating characteristic curve. well (n = 552) 0.29 (p < 0.0001). sensitivity and specificity against 91 % 83 %, respectively. PPV 82.5 %, NPV 91.4 %. all (n = 1233) high, but low moderate groups 3, and 4. appropriate poor 0.08, 0.16, 0.35 g/mmol, can be used predict 0.5 g/day is 0.08 g/mmol (800 mg/g). accurate proteinuria should gold standard test, 24hP.