Correlation between spot and 24h proteinuria: Derivation and validation of equation to estimate daily proteinuria

摘要: Daily urine protein (UP) loss is a cumbersome but important measurement to guide diagnosis and treatment of renal disease. Spot protein-creatinine ratio (UPCR) can been applied estimate daily proteinuria. However, the correlations between spot 24h proteinuria remain controversial. In this cross-sectional study, simultaneous collection urines were performed from 1,039 (derivation cohort) 204 CKD patients (validation Chang Gung Memorial Hospital, 2007 2017. The UPCR compared. mean age derivation validation cohort was 63 55 years estimated glomerular filtration rate 62 ± 35 59 36 mL/min/m2, respectively. correlation coefficient 0.819 24hUP. Prediction equation derived as: Log1024hUP (g) = 0.814 x Log10UPCR (mg/mg) + 0.110 Gender– 0.004 Age Body weight (kg) 0.002 stage coefficient– 0.018, where coefficient: G1 1, G2 2, G3a 3.1, G3b 3.2, G4 4, G5 5. Correlation measured predicted 24hUP among group 0.866 0.915, agreement estimates less pronounced with > 3g than lower values in Bland-Altman analysis. accurately predict below 3g. development may facilitate estimation clinical practice.