FPGA-Controlled All-Solid-State Nanosecond Pulse Generator for Biological Applications
作者： Chenguo Yao , Ximing Zhang , Fei Guo , Shoulong Dong , Yan Mi
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摘要: In vivo studies of tumor-cell apoptosis induced by nanosecond pulsed electric field require high-voltage pulses delivered to the biological tissues. this paper, a newly developed all-solid-state pulse generator based on Marx concept is proposed for application. The comprises four parts: dc charging power, solid-state circuit using metal-oxide-semiconductor field-effect transistors, control field-programmable gate array, and load. This has capability producing repetitive with voltage up 8 kV, pulsewidth 200-1000 ns, rise time 35 repetition rate 1-1000 Hz various resistive loads 1-kV input voltage. design makes compact reliable. Initial experiments were carried out verify performances generator.
sci-hub.se 参考文章(19)
M. Gundersen, P.T. Vernier, L. Marcu, Aimin Li, Xhumei Zhu, A.Z. Gallam, T. Katsouleas, C. Young, M. Behrend, C.M. Craft, Ultrashort pulse electroporation: applications of high pulsed electric fields to induced caspase activation of human lymphocytes international power modulator symposium and high voltage workshop. pp. 667- 670 ,(2002) , 10.1109/MODSYM.2002.1189565
Yifan Wu, Kefu Liu, Jian Qiu, Xiaoxu Liu, Houxiu Xiao, Repetitive and High Voltage Marx Generator Using Solid-state Devices IEEE Transactions on Dielectrics and Electrical Insulation. ,vol. 14, pp. 937- 940 ,(2007) , 10.1109/TDEI.2007.4286529
Juergen F. Kolb, Susumu Kono, Karl H. Schoenbach, Nanosecond pulsed electric field generators for the study of subcellular effects. Bioelectromagnetics. ,vol. 27, pp. 172- 187 ,(2006) , 10.1002/BEM.20185
D. Bortis, J. Biela, J.W. Kolar, Active gate control for current balancing in parallel connected IGBT modules in solid state modulators ieee international pulsed power conference. ,vol. 2, pp. 1323- 1326 ,(2007) , 10.1109/PPPS.2007.4652431
S. M. Huenefeldt, T. G. Engel, W. Clay Nunnally, A 750 KJ Computer Controlled Sequentially-Fired Pulse Forming Network for a Helical Coil Electromagnetic Launcher ieee international pulsed power conference. pp. 237- 240 ,(2005) , 10.1109/PPC.2005.300569
Masahiro Akiyama, Takashi Sakugawa, S. Hamid R. Hosseini, Eri Shiraishi, Tsuyoshi Kiyan, Hidenori Akiyama, High-Performance Pulsed-Power Generator Controlled by FPGA IEEE Transactions on Plasma Science. ,vol. 38, pp. 2588- 2592 ,(2010) , 10.1109/TPS.2010.2042463
C. Yao, C. Sun, Y. Mi, L. Xiong, S. Wang, Experimental studies on Killing and inhibiting effects of steep pulsed electric field (SPEF) to target cancer cell and solid tumor IEEE Transactions on Plasma Science. ,vol. 32, pp. 1626- 1633 ,(2004) , 10.1109/TPS.2004.832621
Dongdong Wang, Jian Qiu, Kefu Liu, All-Solid-State Repetitive Pulsed-Power Generator Using IGBT and Magnetic Compression Switches IEEE Transactions on Plasma Science. ,vol. 38, pp. 2633- 2638 ,(2010) , 10.1109/TPS.2010.2045515
Weihua Jiang, K. Yatsui, K. Takayama, M. Akemoto, E. Nakamura, N. Shimizu, A. Tokuchi, S. Rukin, V. Tarasenko, A. Panchenko, Compact solid-State switched pulsed power and its applications Proceedings of the IEEE. ,vol. 92, pp. 1180- 1196 ,(2004) , 10.1109/JPROC.2004.829003
G.E. Dale, H.C. Kirbie, W.B. Haynes, C.E. Heath, T.A. Lopez, F.P. Romero, R.M. Wheat, Performance of a Diode-Directed Solid-State Marx Modulator ieee international pulsed power conference. pp. 1033- 1036 ,(2005) , 10.1109/PPC.2005.300478