Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties
作者： Lee D Fader , Eddie L Myers , Youla S Tsantrizos
DOI: 10.1016/J.TET.2004.01.026
关键词:
摘要: Aromatic peptide nucleic acid analogs having an N-(2-aminobenzyl)glycine backbone (APNA 1) were previously identified as promising new leads for the design of polyaromatic DNA mimics. Structural modifications 1, which lock aromatic into a unique conformation, while maintaining same space distribution between nucleobases in investigated. The electrostatic potential was also modified attempt to improve solubility these compounds aqueous media and evaluate how quadrapole may influence biophysical properties APNA oligomers. PNA hexamers containing single monomer insert each used explore hybridization with poly rA dA. Preliminary results indicated that do not seriously alter molecular recognition APNAs towards RNA.
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