ACUTE IMMUNE COMPLEX DISEASE IN RABBITS THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS

摘要: By depletion of C3 from rabbits undergoing acute experimental immune complex disease with an anticomplementary factor in cobra venom, it has been possible to demonstrate that deposition the complexes arteries and glomeruli does not require complement components reacting after C2. Immunological reactions, which platelets release their vasoactive amines, have examined disease. A correlation was obtained between presence a complement-independent reaction required blood leukocytes, antigen platelets, complexes, induction glomerulonephritis. did, however, marked alleviating effect on severity arterial lesions. Neutrophil accumulation subsequent necrotizing arteritis were prevented. In contrast, character glomerulonephritis altered by later-acting components.