Novel Penicillin-Type Analogues Bearing a Variable Substituted 2-Azetidinone Ring at Position 6: Synthesis and Biological Evaluation.
作者： Margherita De Rosa , Giovanni Vigliotta , Giuseppe Palma , Carmela Saturnino , Annunziata Soriente
DOI: 10.3390/MOLECULES201219828
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摘要: The synthesis and the biological activity of novel semi-synthetic β-lactam compounds containing an azetidinone moiety joined to amino-nitrogen (+)-6-aminopenicillanic acid (6-APA) as new antibacterial agents is reported. synthesized were screened for their in vitro antimicrobial against a panel Gram positive negative pathogens environmental bacteria. Tested displayed good all tested bacteria Staphylococcus aureus epidermidis resulted higher than that reference antibiotic. Additionally, cytotoxic screening was also carried out indicating do not cause cell vitality reduction effective at concentration next above those shown be antimicrobial.
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