The origin of patterning systems in bilateria-insights from the Hox and ParaHox genes in Acoelomorpha.

摘要: Hox and ParaHox genes constitute two families of developmental regulators that pattern the Anterior-Posterior body axis in all bilaterians. The members these groups are usually arranged genomic clusters work a coordinated fashion, both space time. While mechanistic aspects their action relatively well known, it is still unclear how systems evolved. For instance, we need proper model were assembled over This problem due to shortage information on gene complements for many taxa (mainly basal metazoans) lack consensus phylogenetic animal relationships which can relate our new findings. Recently, several studies have shown Acoelomorpha most probably represent first offshoot Bilateria. finding has prompted us, others, study animals, as activity during development. In this review, analyze current knowledge shaping view bilaterian evolution.