The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis
作者： Shanqi Guo , Xingkang Jiang , Yuanyuan Wang , Liwei Chen , Huzi Li
DOI: 10.1016/J.CELLSIG.2017.07.002
关键词:
摘要: Although previous studies suggested that stress erythropoiesis and iron metabolism regulate each other to increase availability for hemoglobin synthesis, the molecular bases determining its different traits remain elusive. In addition, global DNA demethylation has been reported during mouse in vivo. However, understanding of iron-related genes through under is largely unknown. current study, we found disordered homeostasis misregulated hepcidin-ferroportin axis erythropoiesis. Interestingly, 5hmC content TET2 expression were significantly induced by oxidative stress, whereas antioxidant had opposite's effect. Mechanistic investigation manifested TET2-mediated promotes ferroportin erythroferrone against stress. Besides, NRF2 was increased Elevated could also modulate activation a canonical response element within promoter. These direct indirect pathways synergistically cooperated mediating Our work revealed critical role provided mechanisms underlying epigenetic regulation
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