Growth factors: In vivo function and mechanism of action

摘要: The control of mammalian cell growth is in part regulated by peptide factors that stimulate or inhibit proliferation. number identified regulatory peptides have increased considerably during the last years, as a result purification and characterization new isolation cDNAs for structurally related factors. For description structural functional properties more well characterized factors, see [1]. known can be assigned to different families according their (Table I). Most Table I proliferation, whereas e.g. TGF-s’s, TNF’s IFN’s generally growth. However, single factor act both stimulator inhibitor depending on type culture condition [reviewed ref. 2]. Moreover, also other effects cells, locomotion chemotaxis; several affect differentiation. locally, through autocrine paracrine mechanisms, fact which important keep mind when vivo function discussed.