Association between the PDGF receptor and members of the src family of tyrosine kinases.
作者： Robert M. Kypta , Yves Goldberg , Emin T. Ulug , Sara A. Courtneidge
DOI: 10.1016/0092-8674(90)90013-5
关键词:
摘要: We have examined the interaction between platelet-derived growth factor (PDGF) receptor and three src family tyrosine kinases, pp60c-src, p59fyn, pp62c-yes. The kinase activities of all enzymes were elevated after PDGF stimulation quiescent fibroblasts, coincident with association kinases other proteins. presence a protein 81-85 kd in these complexes correlated detection phosphatidylinositol (PI) activity (previously described to associate both pp60c-src-middle T antigen). These results suggest that physiological response involves not only serine/threonine lipid phospholipase, but also kinases.
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