Signal transduction by receptor tyrosine kinases

摘要: Many oncogenes exert proliferative effects on cells by influencing signal transduction pathways. Signal provides a means for to propagate and amplify signals received from the environment specific targets within cell. The culmination of this pathway is DNA synthesis cell division. Since growth not common event in organs mature multicellular organisms, these pathways must be precisely regulated. signalling process begins at cytoplasmic membrane, where surface receptors interact with factors that are either soluble or present other extracellular matrix. Nontransformed cultured require exogenously supplied stimulate proliferation [1]. In contrast, transformed exhibit partial complete relaxation requirements factors, factor dependence can abrogated expression activated forms proto-oncogenes Oncogene products able overide dependency mimicking actions ligands, their receptors, downstream ordered procession events follow mitogenic stimulation [2]. Each control point potential target deregulation oncoproteins. Thus, an understanding how tumorigenic affect cell’s upon requires identification points characterization interactions between components machinery.