AhR ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis.
作者： George Gaitanis , Prokopios Magiatis , Konstantina Stathopoulou , Ioannis D. Bassukas , Evangelos C. Alexopoulos
关键词:
摘要: Malassezia yeasts are connected with seborrheic dermatitis (SD) whereas M. furfur pathogenicity is associated the production of bioactive indoles. In this study, indoles by isolates from healthy and diseased skin was compared, respective HPLC patterns were analyzed, substances that preferentially synthesized strains isolated SD lesions characterized. Malassezin, pityriacitrin, indole-3-carbaldehyde, indolo[3,2-b]carbazole (ICZ) extracts grown in L-tryptophan agar, identified nuclear magnetic resonance mass spectroscopy. Of these, ICZ, a potent ligand aryl hydrocarbon receptor (AhR), described for first time to our knowledge as metabolite. HPLC-photodiode array detection analysis strain 7 subjects 10 patients showed only consistently produce malassezin ICZ. This discriminatory AhR agonists provides initial evidence previously unreported mechanism triggering development indicates variable recorded furfur-associated conditions may be attributed selective (P<0.001) measurable
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