Synthesis of benzoxazole amides as novel antifungal agents against Malassezia furfur
作者： Beom-Joon Kim , Jin-Ah Kim , Young-Kook Kim , Soon-Yong Choi , Hea-Young ParkChoo
DOI: 10.5012/BKCS.2010.31.5.1270
关键词:
摘要: Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor, atopic dermatitis and fatal sepsis. We report the synthesis of series benzoxazole amides evaluation their antifungal activity against furfur. Twelve were prepared through cyclization substituted 2-hydroxy aniline with N-(bis-methylsulfanylmethylene) amides. Among compounds, compounds 4a, 8b, 8c 8d showed in vitro activity.
koreascience.or.kr参考文章(14)
Barbra Fischer Casagrande, Sabine Flückiger, Maria T. Linder, Catharina Johansson, Annika Scheynius, Reto Crameri, Peter Schmid-Grendelmeier, Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema. Journal of Investigative Dermatology. ,vol. 126, pp. 2414- 2421 ,(2006) , 10.1038/SJ.JID.5700431
Sabiha Alper-Hayta, Mustafa Arisoy, Özlem Temiz-Arpaci, Ilkay Yildiz, Esin Aki, Semiha Özkan, Fatma Kaynak, None, Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles. European Journal of Medicinal Chemistry. ,vol. 43, pp. 2568- 2578 ,(2008) , 10.1016/J.EJMECH.2007.12.019
George Gaitanis, Prokopios Magiatis, Konstantina Stathopoulou, Ioannis D. Bassukas, Evangelos C. Alexopoulos, Aristea Velegraki, Alexios-Leandros Skaltsounis, AhR ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis. Journal of Investigative Dermatology. ,vol. 128, pp. 1620- 1625 ,(2008) , 10.1038/SJ.JID.5701252
P. K. Jauhari, A. Bhavani, Subhash Varalwar, Kiran Singhal, Prem Raj, Synthesis of some novel 2-substituted benzoxazoles as anticancer, antifungal, and antimicrobial agents Medicinal Chemistry Research. ,vol. 17, pp. 412- 424 ,(2008) , 10.1007/S00044-007-9076-X
Özlem Temiz-Arpacı, İlkay Yıldız, Semiha Oezkan, Fatma Kaynak, Esin Akı-Şener, İsmail Yalçın, None, Synthesis and biological activity of some new benzoxazoles European Journal of Medicinal Chemistry. ,vol. 43, pp. 1423- 1431 ,(2008) , 10.1016/J.EJMECH.2007.09.023
Karla Carvalho Miranda, Crystiane Rodrigues de Araujo, Carolina Rodrigues Costa, Xisto Sena Passos, Orionalda de Fátima Lisboa Fernandes, Maria do Rosário Rodrigues Silva, Antifungal activities of azole agents against the Malassezia species. International Journal of Antimicrobial Agents. ,vol. 29, pp. 281- 284 ,(2007) , 10.1016/J.IJANTIMICAG.2006.09.016
M. Augustin, M. Richter, S. Salas, Reaktionen mit N‐Acylimino‐dithiokohlensäurediestern Journal Fur Praktische Chemie-chemiker-zeitung. ,vol. 322, pp. 55- 68 ,(1980) , 10.1002/PRAC.19803220109
Sho Yamasaki, Makoto Matsumoto, Osamu Takeuchi, Tetsuhiro Matsuzawa, Eri Ishikawa, Machie Sakuma, Hiroaki Tateno, Jun Uno, Jun Hirabayashi, Yuzuru Mikami, Kiyoshi Takeda, Shizuo Akira, Takashi Saito, C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 1897- 1902 ,(2009) , 10.1073/PNAS.0805177106
Tugba Ertan, Ilkay Yildiz, Betul Tekiner-Gulbas, Kayhan Bolelli, Ozlem Temiz-Arpaci, Semiha Ozkan, Fatma Kaynak, Ismail Yalcin, Esin Aki, Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents. European Journal of Medicinal Chemistry. ,vol. 44, pp. 501- 510 ,(2009) , 10.1016/J.EJMECH.2008.04.001
A. Gonzalez, R. Sierra, M. E. Cardenas, A. Grajales, S. Restrepo, M. C. Cepero de Garcia, A. Celis, Physiological and Molecular Characterization of Atypical Isolates of Malassezia furfur Journal of Clinical Microbiology. ,vol. 47, pp. 48- 53 ,(2009) , 10.1128/JCM.01422-08