Significance of alternative splicing in cancer cells.
作者： Fei Qi , Yong Li , Xue Yang , Yan-Ping Wu , Lian-Jun Lin
DOI: 10.1097/CM9.0000000000000542
关键词:
摘要: Objective: Alternative splicing can generate various structural and functional protein isoforms. Recently, accumulating evidence shows a relationship between alternative cancer. Cancer is complex chronic disease that involves malignant transformation. In this review, we consider events in relation to the hallmarks of cancer cells, discuss current therapies treat cancer-related splicing. Data sources: Data cited article are from PubMed Embase database, primarily focusing on research published 2000 2018. Study selection: Articles were selected with search terms "alternative splicing," "cancer cell," "tumor microenvironment," "therapy." Results: Alternative plays an important role tumorigenesis, development, escape cell death. Taking trait cells into consideration will allow more definite diagnoses cancer, development effective medicines intervene could focus controlling or competitively binding final products. Conclusions: Alternative common cells. Consideration may different strategies for therapy identification novel biomarkers diagnosis. Key words: Alternative splicing; Cancer cell; Hallmark; Therapy; Tumor microenvironment
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