Myocardial Macrophage Phenotypic Variation and Cytokine-Mediated Induction of HIV-Associated Cardiac Disease: A Dissertation

摘要: Ventricular dysfunction and dilated cardiomyopathy (DCM) develop among untreated HIV-infected people at much higher rates than HIV-negative individuals, resulting in significant contributions to morbidity mortality. Mechanisms underlying development of HIV-associated (HIVCM) are as yet poorly understood. The well-characterized simian immunodeficiency virus (SIV) model HIV infection provides a unique context for HIVCM pathogenesis studies that SIV-infected rhesus monkeys myocardial lesions contractile similar those described people, suggesting shared disease mechanism. Lymphocytic myocarditis is commonly reported finding AIDS patients autopsy constitutes one several conditions known predispose DCM, irrespective HIV-infection status. As lymphocytic also occurs with high frequency monkeys, retrospective analysis monkey cardiac tissue collected necropsy was performed examine viral cellular correlates inflammation within tissue. One subpopulation macrophages, which has been by other groups be associated an antiinflammatory phenotype, found correlate inversely infiltration positively numbers infected cells, effects cytokine production profile. In contrast, the detrimental inflammatory cytokines on structure function well-recognized general characterized chronic immune activation dysregulation. To further