Prognostic relevance of pre- and postoperative plasma l-lactate measurements in calves with acute abdominal emergencies.

摘要: In both human and veterinary medicine, l-lactate is a well-established prognostic biomarker of disease severity mortality has also attracted increasing attention in bovine medicine due to the availability validation cheap portable analyzers. The aim present study was evaluate accuracy plasma L-lactate measurements calves with acute abdominal emergencies before during initial therapeutic period after surgical intervention. A prospective observational carried out involving 83 hospitalized up an age 7 mo, which required intervention for reasons emergency such as gastrointestinal ileus or peritonitis. Plasma (L-LAC) concentrations were determined immediately initiation surgery 6, 12, 24, 48, 72 h later. outcome evaluated 3 mo discharge by phone call farmer, positive defined if calf still alive owner satisfied animal's postsurgical progress. total 29% discharged from hospital proportion 3-mo 24%. At all sampling times first 48 intervention, negative had significantly higher L-LAC than outcome. binary logistic regression analysis indicated that odds observation increased factor 1.23 [95% confidence interval (CI): 1.04-1.44] every mmol/L increase but 5.29 (95% CI: 1.69-16.6) 5.92 1.29-27.3) at 12 24 h, respectively. largest area under receiver operating characteristic curve observed (0.91; 95% 0.83-0.99), cut-point 2.75 identified sensitivity specificity predicting 68 100%, conclusion, persistent hyper-l-lactatemia early postoperative more reliable indicator Postoperative are therefore clinically useful tool identify patients risk stage out.