Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase Cε, and endothelin system in diabetic rats.

摘要: Objectives  Phosphodiesterase type 5 inhibitors are potent in relieving erectile dysfunction (ED), however, they less satisfactory diabetic patients, probably due to the pro-inflammatory biomarkers caused by diabetes. Therefore, it was interesting compare effects of sildenafil with strontium fructose 1,6-diphosphate (FDP-Sr) on cavernosal vascular activity and expressions rats. Methods  Male Sprague-Dawley rats were injected streptozocin (60 mg/kg, i.p.) develop The animals for eight weeks (12 mg/kg per day) or FDP-Sr (200 mg/kg being administered last four those weeks. Key findings  Sildenafil more effective reduced dilatation (relevant ED), but attenuating over-expressions NADPH oxidase p22, p47 p67 subunits, ETA/BR (endothelin receptor A B) cavernosum. In contrast, improving ED, normalizing abnormal ETA/BR. Conclusions  activated upregulated ETAR ETBR lesions played a minor moderate role ED. By offering extra ATP, FPD-Sr suppressed these abnormalities, did not. combined therapy may be ED patients through cytokines nitric oxide/cGMP pathway