Hexavalent chromium induced oxidative stress and apoptosis in Pycnoporus sanguineus.

摘要: Abstract White rot fungi have been proved to be a promising option for the removal of heavy metals, understanding their toxic response metals is conducive developing and popularizing fungi-based remediation technologies so as lessen hazard metals. In this study, Cr(VI)-induced oxidative stress apoptosis in Pycnoporus sanguineus, species white were investigated. The results suggested that high level Cr(VI) promoted formation ROS, including H 2 O , •− ·OH. With increment concentration, SOD CAT activity along with GSH content increased within first 24 h, but decreased afterward, companied significant enhancement MDA content. damage further caused aggravated P. especially at concentrations above 20 mg/L. was involved mitochondrial dysfunction depolarization, permeability release cytochrome c. early late hallmarks, such metacaspase activation, phosphatidylserine (PS) externalization, DNA fragmentation nuclear condensation observed. Moreover, we also found disturbances ion homeostasis, which featured by K + effluxes overload cytoplasmic Ca 2+ .Based on these results, suggest induced fungi, sanguineus .