Characterizing Deformability of Drug Resistant Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells Using Acoustic Tweezers

摘要: The role of cell mechanics in cancer cells is a novel research area that has resulted the identification new mechanisms therapy resistance. Single beam acoustic (SBA) tweezers are promising technology for quantification mechanical phenotype cells. Our previous study showed SBA can be used to quantify deformability adherent breast lines. physical properties patient-derived (primary) pre-B acute lymphoblastic leukemia (ALL) involved chemotherapeutic resistance have not been widely investigated. Here, we demonstrate feasibility analyzing primary ALL from four cases using tweezers. increased with increasing pressure Moreover, resistant drugs were more deformable than untreated We demonstrated nonadherent and discriminate this chemotherapy-resistant contact- label-free manner.