Evaluation of regional liver damage by magnetic resonance imaging with superparamagnetic iron oxide in rat liver.
作者： Takamichi Murakami , Tonsok Kim , Manabu Takamura , Junzo Shimizu , Masatoshi Hori
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摘要: The purpose of this study was to investigate whether regional liver damage could be detected by means enhanced MR imaging with a superparamagnetic iron oxide (SH U 555A) in an ischemia–reperfusion model rat liver. Ischemic induced the right lobe vascular clamping for 0 (sham), 30 (I-30), 60 (I-60), and 90 minutes (I-90). There no significant difference relative enhancement (RE) between ischemic nonischemic lobes sham, I-30 I-60 groups, while RE significantly lower than that its counterpart I-90 group as seen on SH 555A proton density spin echo images (P < 0.05). Histological examination revealed deposits were smaller 0.05), although there number Kupffer cells. Our results indicate severe can evaluated 555A.
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