Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate
作者： N Matsukura , T Kawachi , K Morino , H Ohgaki , T Sugimura
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摘要: The compounds 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole, which are potent mutagens in a tryptophan pyrolyzate, ar hepatic carcinogens when given orally to mice at concentrations of 200 parts per million pellet diet. Female showed higher susceptibilities both than male mice.
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