Nonequivalence of surgical and natural denervation in dystrophic mouse muscles.

摘要: Abstract The electrical “cable” properties of fibers in the soleus muscle normal and dystrophic mice were measured vitro at 37C with intracellular microelectrodes. motor nerve was stimulated to determine whether or not chosen for measurement functionally innervated. Normal muscles which had been surgically denervated also studied. Specific membrane resistance higher than fibers; respective mean values 1516 636 ohm cm 2 . Dystrophic innervated significantly those innervated, but neither case did approach normal. In both muscles, previous sectioning led an increase fiber input resistance. Surgically considerably become during course disease. results suggest that denervation per se cannot account differences between fibers.