Chromosomal Instability and Tumors Promoted by DNA Hypomethylation
作者： Amir Eden , François Gaudet , Alpana Waghmare , Rudolf Jaenisch
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摘要: Human tumors often display changes in DNA methylation, including both genome-wide hypomethylation and site-specific hypermethylation ( [1][1], [2][2] ). In mice, is sufficient to induce T cell lymphomas with consistent gain of chromosome 15 [3][3] ), indicating that
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