Cellular-signaling pathways unveil the carcinogenic potential of chemicals

摘要: Most of the current in vitro carcinogenicity assays assess potential carcinogenic properties chemicals through detection inflicted DNA damage or subsequent chromosome and gene mutations. Unfortunately, these generally do not provide mechanistic insight into reactive a chemical. Upon chemical-induced biomolecules, molecular sensors will activate general damage-specific cellular response pathways that protection against (geno)toxic chemicals. These defense mechanisms include activation cell-cycle checkpoints, repair systems induction apoptosis necrosis. Visualization activated cellular-signaling forms powerful means to readily detect genotoxic chemical compounds simultaneously gain their properties. Over past years, various reporter have been developed monitor more specific pathways, including GreenScreen HC ToxTracker assays. In this review we perspective on how can exploit signaling shed light mode action exposure develop sophisticated mechanism-based for cancer risk assessment. Copyright © 2013 John Wiley & Sons, Ltd.