SmartPDT®: Smartphone enabled real-time dosimetry via satellite observation for daylight photodynamic therapy.

摘要: Abstract Background Actinic keratosis (AK) affects one quarter of over 60  year olds in Europe with the risk transforming into invasive squamous cell carcinoma. Daylight photodynamic therapy (dPDT) is an effective and patient preferred treatment that uses sunlight to clear AK. Currently, there no standardised method for measuring light received during treatment. Methods SmartPDT® a smartphone-based application web-portal, developed by siHealth Ltd, enabling remote delivery dPDT. It satellite imagery computational algorithms provide real-time determination exposure PpIX-effective solar radiation (“light dose”). The also provides forecast expected radiant exposures 24- 48-hs prior period. Validation forecasted was performed against direct ground-based measurement under all weather conditions Chilton, UK. Results Agreement between ground measurements satellite-determined 2-h excellent at −0.1 % ± 5.1 (mean ± standard deviation). There agreement measurement, 1.8 17.7 24-hs 1.6 25.2 48-hs. Relative Root Mean Square Error (RMSEr) demonstrated improved as time reduced (RMSEr = 22.5 (48 -hs), 11.2 (24-hs), 5.2 (real-time)). Conclusion satellite-determined, weather-forecasted ground-measured better than any existing published literature web-portal has potential assist dPDT, important factor reducing elderly population Covid-19 pandemic.