Reduction of leptin levels by four cardiac hormones: Implications for hypertension in obesity.

摘要: Circulating levels of leptin are increased in obesity and have been proposed to contribute the development hypertension obese individuals. Four cardiac hormones, specifically, vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic atrial (ANP), blood pressure-lowering properties correlate with presence obesity. The objective this study was determine whether one or more these hormones able decrease hypothalamus, an area brain that has demonstrated synthesize than 40% circulation. effects four on were examined using dose-response curves rat which synthesizes leptin. Vessel LANP, ANP maximally decreased hypothalamic cells by 79, 76, 80 62%, respectively (P<0.0001 for each). over a concentration range 100 pM 10 μM, most significant reductions occurring when concentrations at micromolar levels. results suggest lead levels, may be important mechanism alleviating leptin-induced