In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity.

摘要: A decreased mobilization of triglycerides may contribute to fat accumulation in adipocytes, leading obesity. However, this hypothesis remains be proven. In study, epinephrine-induced lipid was investigated vivo nine markedly obese children (160+/-5% ideal body weight) aged 12.1+/-0.1 yr during the dynamic phase deposition, compared with six age-matched nonobese children. As an index lipolysis, we measured glycerol flux using a nonradioactive tracer dilution approach, and plasma free fatty acid concentrations. basal state, had 30% lower rate release per unit mass than lean To study regulation epinephrine infused stepwise at fixed doses 0.75 then 1. 50 microg/min both groups. children, increased average 249-246% values, respectively, response mean 396+/-41 pg/ml. The corresponding increase only 55-72% although their reached 606+/-68 All except Arg64Trp heterozygote, were homozygotes for Trp position 64 beta3-adrenoreceptor. resistance lipolysis showed no relationship Arg64 polymorphism beta3-adrenoreceptor gene. summary, which mostly reflects stores from subcutaneous adipose tissue, shows sensitivity childhood onset Since our carried out accumulation, observed catecholamines might possibly causative rather result