Systematic Regional Variations in the Loss of Cortical Cholinergic Fibers in Alzheimer's Disease

摘要: The loss of cortical cholinergic fibers in Alzheimer's disease was investigated using choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Within both the normal cerebral cortex, two methods revealed an identical pattern fiber staining. In brain, density highest limbic paralimbic zones, intermediate most sensory-motor association lowest within primary visual areas occipital lobe. general, supragranular layers contained a higher fibers, these were oriented vertically. disease, overall 55% detected. There was, however, marked regional variations extent this different areas. Cortical temporal lobe, particularly areas, displayed dramatic fibers. By contrast, anterior cingulate visual, somatosensory, motor cortex relative preservation As whole, greater detected vertical to surface. These results indicate that cholinomimetic therapies are likely have effects on transmission various precise mechanisms lead denervation remain be elucidated.