A theory of drug tolerance and dependence II: the mathematical model.

摘要: Abstract The preceding paper presented a model of drug tolerance and dependence. assumes the development to repeatedly administered be result regulated adaptive process. oral detection analysis exogenous substances is proposed primary stimulus for mechanism tolerance. Anticipation environmental cues are in considered secondary stimuli, becoming dependence addiction or when administration bypasses natural—oral—route, as case drugs intravenously. considers adaptation effect interval between taking autonomous processes. Simulations with mathematical demonstrate model's behaviour consistent important characteristics drugs: gradual decrease develops, high sensitivity small changes dose, rebound phenomenon large reactions following withdrawal present discusses terms its design. nonlinear, learning feedback system, fully satisfying control theoretical principles. It accepts any form stimulus—the intake—and describes how physiological processes involved affect distribution through body stability regulation loop. verifies theory provides basis implementation models specific