Evaluation of a Novel Isotope Biomarker for Dietary Consumption of Sweets

摘要: Carbon isotopic signatures ("δ¹³C") might reflect consumption of corn- and cane-based sweeteners. The authors hypothesized that the δ¹³C value human serum is higher for individuals with high versus low intakes sweeteners (measured as sweetened beverage intake). They conducted a cross-sectional study within Atherosclerosis Risk in Communities Magnetic Resonance Imaging (Maryland, 2005-2006). Diet was assessed by food frequency questionnaire, blinded samples were assayed natural abundance stable isotope mass spectroscopy. Studied 186 participants (53% male; mean age, 71 years; body index, 30 kg/m²). Serum values significantly than those (-19.15‰ vs. -19.47‰, P < 0.001). increased 0.20‰ every serving/day beverages (P 0.01). association between remained significant after adjustment confounding corn-based product intake also associated waist circumference, waist-to-hip ratio. This provides first known evidence differs persons consuming amounts sweets. Within proper framework, could be developed into an objective biomarker promoting more reliable assessment dietary sweets intake.