Haematologic alterations caused by Ipomoea carnea in experimental poisoning of guinea pig
作者： Enrique N. García , María V. Aguirre , Eduardo J. Gimeno , Elvio E. Rios , Ofelia C. Acosta
DOI: 10.1016/J.ETP.2015.07.002
关键词:
摘要: Ipomoea carnea subsp. fistulosa (Convolvulaceae) causes poisoning of goats, sheep and cattle in many tropical subtropical countries. The pathophysiology this mainly involves an abnormal glycoprotein metabolism. aim study was to describe the potential toxicity I. a guinea pig model through its effect on hematopoiesis time course 40 days. Experimental achieved by feeding animals with “small balls” prepared milled leaves mixed commercial crushed pellets for rodents. Hematologic biochemical parameters, bone marrow spleencellularities, histopathologic evaluations lectin-histochemistrywere performed during scheduled study.The treatment caused significant changes weight spleen, notable decrease peripheral red blood cells, concomitantwith morphological histopathologicalalterationsin hematopoietic tissues. Overall, present suggested that 20 days ofthis treatmentcouldbe enough develop hypoplasia vacuolation white cells lymph nodes transient erythropoietic contribution splenic niche.Moreover, work provides cheap simple method detecting preclinical cases intoxication livestock.
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